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01Fred Hutch's HSV gene therapy in 2026: mouse and guinea-pig results, no human trial, and the antivirals arriving firstA gene therapy clears up to 97% of dormant herpes in mice. In the animal that relapses the way people do it clears above 30%, nobody has filed to test it in a person, and the drugs arriving first suppress the virus rather than remove it.ArticleDrugs & public health20 quotes · 1 source · 6 min10 Oct
02Opioid deaths and overdose calls in Hamilton: why the two counts moved in opposite directionsHamilton's opioid deaths have fallen every year since 2021, while paramedic calls for overdoses more than doubled. The death count is measuring a drug supply that no longer exists.ArticleDrugs & public health45 quotes · 2 sources · 7 min10 Oct
03The Fringe Pharmacopeia of HSV Latency Destruction: A Deep-Hunt Survey of Natural, Botanical, Fungal, and Bioactive CompoundsNo natural compound has been shown to destroy or eradicate HSV latency in human neurons.ResearchDrugs & public health14 figures · 5 sourcesSep
04Novel and Underexplored Mechanisms for Disrupting and Destroying HSV Latency: A Mechanistic Research PassThe single most mature "destruction" approach is AAV-delivered meganuclease gene editing, which eliminated over 90% of latent virus from mouse superior cervical ganglia (Aubert et al.ResearchResearch passDrugs & public health9 figures · 8 sourcesSep
05The State of HSV Gene-Therapy Development: Fred Hutch's Meganuclease Program and the Broader Herpes-Cure PipelineThe Fred Hutch/Jerome-lab HSV meganuclease program remains preclinical (pre-IND) as of mid-2026 — no IND has been filed and no human trial has begun.ResearchDrugs & public health29 figures · 4 sourcesSep
06The Fentanyl Crisis Research Synthesis: Sharpest Evidence for a Long-Form Hamilton/Ontario EssayThis synthesis is organized by the four focus areas in your brief.ResearchResearch briefDrugs & public health46k characters22 Jul
07How We Got Here: A Field Guide to the Fentanyl Crisis in Canada and on Hamilton's StreetsHamilton in 2026 — the open wounds, the forward-leaning catatonia, the people who appear neither awake nor unconscious but suspended in some grotesque middle state — is not the same drug crisis Canada has been talking about for the last decade.ResearchResearch briefDrugs & public health40k characters22 Jul